What is Sakae Naa? Benefits and Uses

Combretum quadrangulare, colloquially known as Sakae Naa, is a Southeast Asian tree that produces leaves that resemble and taste like kratom (Mitragyna speciosa).

This tropical tree is found in marshes and jungles along riverbanks in Laos, Thailand, Vietnam, Cambodia, and Myanmar (Burma). This article will look at Sakae Naa, its traditional use, chemical composition, and potential benefits and drawbacks.

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Botanical Information

Sakae Naa is a herbaceous perennial plant that grows to a height of 60-90 cm. The plant is distinguished by thin, green stems and small, white blooms that develop in clusters at the plant's crown.

The leaves are lanceolate in shape and are placed on the stalk opposite each other. The bitter taste of the plant is due to the presence of andrographolide, the plant's major active component. The plant's leaves and stem are often used to produce tea, which is drunk for its medicinal benefits.


Sakae Naa has been used in traditional medicine in Southeast Asia for generations. It has been used as a natural cure for a variety of ailments including fever, respiratory infections, and digestive problems. The plant's leaves and stem are often used to produce tea, which is drunk for its medicinal benefits. It's also popular in Ayurvedic medicine.

Sakae Naa is an ancient Southeast Asian medicinal herb that has become popular in recent years as many have begun to recognize its distinct healing properties. Sakae Naa can be used to treat a variety of conditions, including digestive issues, headaches, pain relief without resorting to harmful medications, and even cancer.

Sakae Naa also reduces stress and lowers blood pressure and cholesterol levels.  

Chemical Composition

Sakae Naa's major active ingredient is andrographolide. This chemical gives the plant its anti-inflammatory and immune-boosting benefits. 14-deoxy-11,12-didehydroandrographolide, andrographiside, and neoandrographolide are some of the other chemicals discovered in the plant. These chemicals also contribute to the therapeutic benefits of the plant.

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Modern Research

Despite its long history, recent research on Sakae Naa is sparse. However, research have revealed that the herb may have medical benefits. Andrographolide contains anti-inflammatory and anti-viral qualities, which can help with illnesses including fever and respiratory infections, according to research.

Furthermore, studies have shown that it can aid with digestive difficulties. More research is needed to fully understand its benefits and potential adverse effects.

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Sakae Naa's anti-inflammatory effects are one of its key advantages. Inflammation is the body's normal response to damage or infection, but persistent inflammation can lead to a variety of illnesses including arthritis, heart disease, and cancer.

Sakae Naa's major active ingredient, andrographolide, has anti-inflammatory qualities, making it a viable natural therapy for ailments such as arthritis and other inflammatory diseases.

Researchers assessed the antihelminthic effectiveness of Sakae Naa seeds in one study by analyzing their interactions with roundworms in buffalo calves.

Within 1-3 weeks, a single oral intake of Sakae Naa seeds reduced the amount of Neoascaris vitulorum eggs in the calves' excrement to zero.

The seeds did not produce fatalities or toxicity even at large doses, according to the authors.

Sakae Naa contains anti-bacterial characteristics in addition to anti-inflammatory and anti-viral capabilities, making it a viable natural therapy for bacterial infections such as respiratory infections and urinary tract infections.

Anti-bacterial capabilities of andrographolide have been discovered, which can help to lessen the intensity of symptoms and shorten the length of the infection. In a 2006 study, the scientists discovered that extracts from the plant's seeds effectively killed specific types of bacteria.

Interestingly, the same Sakae Naa researchers discovered that the plant's seeds could be safely preserved and used for years if kept away from air and moisture, indicating that Sakae Naa could have a sustainable shelf life as a therapeutic agent as well.

While Sakae Naa may have medicinal characteristics, more research is needed to know the full range of its benefits and potential adverse effects.

Before taking this supplement, as with any other, see a healthcare expert, especially if you are presently taking any drugs.

Your doctor can advise you on the proper dosage as well as any potential conflicts with other medications or supplements you may be taking.

Adverse Side Effects

Sakae Naa is usually regarded as safe when used as advised. Dry mouth, constipation, and decreased appetite are common adverse effects of Combretum quadrangulare leaf consumption. However, the long-term adverse effects of Sakae Naa are still unknown.

Before taking Sakae Naa, contact a healthcare provider, especially if you are pregnant, breastfeeding, or taking other medications. This is to check that you are taking the correct dosage and that it is safe for you.

Drug Interactions

There is little information available about Sakae Naa's potential interactions with other drugs. Before beginning any new supplement, consult with a healthcare practitioner, especially if you are presently taking any drugs.

Dosage and Administration

Sakae Naa dose and administration differ depending on the condition being treated and the individual taking the supplement. Before using Sakae Naa, speak with a healthcare expert to discover the best dosage for you. There is no general dose recommendation. However, some companies recommend dosages around 5 to 10 grams.

The indigenous smoked or chewed the leaves of it to reap its benefits.Furthermore, because of the lack of varied strains and varieties, Sakae Naa is usually commercially found in a powdered or crushed form. It is critical to follow the product label directions and not exceed the suggested dosage.

When making Sakae Naa tea, steep the leaves for at least 10-15 minutes to ensure full extraction of the medicinal components. It is also crucial to note that some people may be sensitive to the harsh flavor of the herb and may want to sweeten or honey the tea.

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Trying Sakae Naa 

Sakae Naa is a shrub that grows in Thailand, Cambodia, and Laos. The leaves of the Sakae Naa plant have been traditionally used for their medicinal properties.

Some of the reported benefits of Sakae Naa include relief from pain, improved cognitive function, and increased energy levels. If you’re looking for an all-natural way to boost your energy levels, try our Kratom & Kava Shot.

Our shot can help you get through your day without relying on harmful artificial stimulants.

Related Link: How to Make Kava Taste Better

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